As a professional Researcher, the main goal of my research is to understand how scientific processes are responsible for producing the interactions and measurements observed in the experiments and projects I work on. I use a combination of approaches and technologies specially developed for use in my studies. Learn more about my research and areas of study below.
N-Heterocyclic Carbene (NHC)-Organocatalysis
N-Heterocyclic carbene-catalysis has been used for the umpolung of aldehydes, and more recently to the umpolung of Michael acceptors and imines. The fundamental mode of carbene reactivity in organocatalysis is via the generation of nucleophilic Breslow intermediates (umpolung) by the addition of aldehydes to NHCs. The two well-known reactions proceeding via the umpolung of aldehydes are benzoin condensation and Stetter reaction. Moreover, the addition of enals to NHCs resulted in the generation of homoenolate equivalents (conjugate umpolung). In addition, NHCs are also known for catalyzing non-umpolung transformations.
Synthesis of Functionalized Dihydrocoumarins by NHC-Catalyzed [3+3] Annulation of Enals with 2-Substituted Naphthoquinones.
Shee, S.; Barik, S.; Ghosh, A.; Biju, A. T.
NHC-Catalyzed Desymmetrization of N-Aryl Maleimides Leading to the Atroposelective Synthesis of N-Aryl Succinimides.
Barik, S.; Shee, S.; Das, S.; Gonnade, R. G.; Jindal, G.; Mukherjee, S.; Biju, A. T.
Enantioselective Synthesis of Tricyclic β‑Lactones by NHC-Catalyzed Desymmetrization of Cyclic 1,3-Diketones.
Shee, S.; Mukherjee, S.; Gonnade, R. G.; Biju, A. T.