top of page
Welcome to My Home Page

I'm Sayan Shee, a Research Scholar at the Department of Organic Chemistry, Indian Institute of Science (IISc) Bangalore. My research focuses on Sustainable N-Heterocyclic Carbene (NHC)-Organocatalysis. Learn more about my research and areas of study below.

  • ResearchGate
  • Facebook
  • Google Scholar
  • LinkedIn
  • Twitter

Sayan Shee

Research Scholar

Research Interest

N-Heterocyclic Carbene (NHC)-Organocatalysis

N-Heterocyclic carbene-catalysis has been used for the umpolung of aldehydes, and more recently to the umpolung of Michael acceptors and imines.​ The fundamental mode of carbene reactivity in organocatalysis is via the generation of nucleophilic Breslow intermediates (umpolung) by the addition of aldehydes to NHCs. The two well-known reactions proceeding via the umpolung of aldehydes are benzoin condensation and Stetter reaction. Moreover, the addition of enals to NHCs resulted in the generation of homoenolate equivalents (conjugate umpolung). In addition, NHCs are also known for catalyzing non-umpolung transformations. 

Selected Publications

  • Enantioselective Synthesis of C-O Axially Chiral Diaryl Ethers via NHC-Catalyzed Atroposelective Desymmetrization.

        Shee, S.; Ranganathappa, S. S.; Gadhave, M. S.; Gogoi, R.; Biju, A. T.

       Angew. Chem. Int. Ed. 2023, 62, e202311709. 

  • N-Heterocyclic Carbene-Catalyzed aza-Michael-Mannich-Lactamization Cascade for the Enantioselective Synthesis of Pyrazoloquinolin-3-ones.

        Shee, S.; Sarkar, D.; Biju, A. T.

        Org. Lett. 2023, 25, 220-225. 

  • NHC-Catalyzed Desymmetrization of N-Aryl Maleimides Leading to the Atroposelective Synthesis of N-Aryl Succinimides.

       Barik, S.; Shee, S.; Das, S.; Gonnade, R. G.; Jindal, G.; Mukherjee, S.; Biju, A. T.

       Angew. Chem. Int. Ed. 2021, 60, 12264-12268.

  • Enantioselective Synthesis of Tricyclic β‑Lactones by NHC-Catalyzed Desymmetrization of Cyclic 1,3-Diketones.

       Shee, S.; Mukherjee, S.; Gonnade, R. G.; Biju, A. T.

       Org. Lett. 2020, 22, 5407-5411. 

bottom of page